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:::::Pain Physician:::::
 
Past Issue - March 2011 - Vol 14 Issue 2 Index | Previous | Next | 
2011;14;91-121. A Systematic Review of Randomized Trials of Long-Term Opioid Management for Chronic Non-Cancer Pain
Systematic Review
Laxmaiah Manchikanti, MD, Hary Ailinani, MD, Dhanalakshmi Koyyalagunta, MD, Sukdeb Datta, MD, Vijay Singh, MD, Ike Eriator, MD, Nalini Sehgal, MD, Rinoo V. Shah, MD, Ramsin M. Benyamin, MD, Ricardo Vallejo, MD, PhD, Bert Fellows, MA, and Paul J. Christo, MD
 

BACKGROUND: Even though opioids have been used for pain for thousands of years, opioid therapy for chronic non-cancer pain is controversial due to concerns regarding the long-term effectiveness and safety, particularly the risk of tolerance, dependance, or abuse. While the debate continues, the use of chronic opioid therapy for chronic non-cancer pain has increased exponentially. Even though evidence is limited, multiple expert panels have concluded that chronic opioid therapy can be effective therapy for carefully selected and monitored patients with chronic non-cancer pain.

STUDY DESIGN: A systematic review of randomized trials of opioid management for chronic non-cancer pain.

OBJECTIVE: The objective of this systematic review is to evaluate the clinical efficacy of opioids in the treatment of chronic non-cancer pain.

METHODS: A comprehensive evaluation of the literature relating to opioids in chronic non-cancer pain was performed. The literature was evaluated according to Cochrane review criteria for randomized controlled trials (RCTs) and Jadad criteria.

A literature search was conducted by using PubMed, EMBASE, Cochrane library, ECRI Institute Library, U.S. Food and Drug Administration (FDA) website, U.S. National Guideline Clearinghouse (NGC), Database of Abstracts of Reviews of Effectiveness (DARE), clinical trials, systematic reviews and cross references from systematic reviews.

The level of evidence was classified as good, fair, or poor based on the quality of evidence developed by the United States Preventive Services Task Force (USPSTF) and used by other systematic reviews and guidelines.

OUTCOME MEASURES: Pain relief was the primary outcome measure. Other outcome measures were functional improvement, withdrawals, and adverse effects.

RESULTS: Based on the USPSTF criteria, the indicated level of evidence was fair for Tramadol in managing osteoarthritis. For all the drugs assessed, including Tramadol, for all other conditions, the evidence was poor based on either weak positive evidence, indeterminate evidence, or negative evidence.

LIMITATIONS: A paucity of literature, specifically with follow-up beyond 12 weeks for all types of opioids with controlled trials for various chronic non-cancer pain conditions.

CONCLUSIONS: This systematic review illustrated fair evidence for Tramadol in managing osteoarthritis with poor evidence for all other drugs and conditions. Thus, recommendations must be based on non-randomized studies.

 

   
 
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Pain Physcian
Authors
Paul J. Christo
Ricardo Vallejo
Bert Fellows
Ramsin M. Benyamin
Rinoo V. Shah
Nalini Sehgal
Ike Eriator
Vijay Singh
Sukdeb Datta
Hary Ailinani
Dhanalakshmi Koyyalagunta
Laxmaiah Manchikanti


Keywords
Chronic non-cancer pain
opioids
opioid efficacy
opioid effectiveness
significant pain relief
functional improvement
adverse effects
morphine
hydrocodone
hydromorphone
fentanyl
tramadol
buprenorphine
methadone
tapentadol
oxycodone