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2012;15;E515-E522. The Long-Term Incidence of Subsequent Vertebral Body Fracture After Vertebral Augmentation Therapy: A Systematic Review and Meta-Analysis
Systematic Review
Jun Zou, MD, PhD, Xin Mei, MD, Xuesong Zhu, MD, PhD, Qin Shi, MD, PhD, and Huilin Yang, MD

BACKGROUND: Vertebroplasty and kyphoplasty have recently been used to treat painful osteoporotic compression fractures. Early clinical results have been encouraging, but very little is known about the consequences of augmentation with cement for adjacent, unaugmented levels.

OBJECTIVE: This study performed a systemic review of the studies concerning whether the incidence of subsequent vertebral body fracture after vertebral augmentation therapy would be increased long-term.

STUDY DESIGN: A meta-analysis of randomized controlled trials was performed comparing the long-term incidence of subsequent vertebral body fracture between vertebral augmentation surgeries like vertebroplasty and kyphoplasty and conventional nonsurgical management.

SETTING: The MEDLINE, EMBASE, ISI Web of Science and Cochrane Library databases and abstracts published in annual proceedings were systematically searched for evidence.

METHODS: Relevant reports were reviewed by 2 reviewers independently and the references from these reports were searched for additional trials, using guidelines set by QUOROM statement criteria.

RESULTS: Pooled results from 2 randomized controlled trials showed no significant increase of the secondary fracture rate after vertebral augmentation therapy compared with that of conventional treatment (P = 0.07). Few large-sample randomized controlled trials were specifically performed to investigate new fractures as an outcome of vertebroplasty or kyphoplasty.

LIMITATIONS: There were few data sources from which to extract abstracted data or published studies. There were only 2 randomized controlled trials that met criteria.

CONCLUSIONs: Although vertebral augmentation therapies, such as vertebroplasty and kyphoplasty, have been widely used in clinics to treat patientsí back pain caused by vertebral compression fractures due to osteoporosis, no evidence shows that they can increase the fracture of adjacent vertebral bodies.


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Pain Physician
Jun Zou
Xin Mei
Xuesong Zhu
Qin Shi
Huilin Yang

subsequent vertebral fracture
systemic review
meta analysis.